CD274 [B7-H1/PD-L1] Recombinant eiwit

Programmed death ligand 1 (PD-L1, B7-H1 or CD274) is a member of the growing B7 family of immune proteins that provide signals for both stimulating and inhibiting T cell activation. CD274 has been identified as one of two ligands for programmed death 1 (PD-1), a member of the CD28 family of immunoreceptors. CD274 is widely expressed in several organs such as heart, skeletal muscle, placenta and lung, and in lower amounts in thymus, spleen, kidney and liver. CD274 expression is upregulated in a small fraction of activated T and B cells and a much larger fraction of activated monocytes. CD274 expression is also induced in dendritic cells and keratinocytes after IFN-gamma stimulation. CD274 expression is also upregulated in a variety of tumor cell lines. Interaction of CD274 with PD-1 results in inhibition of TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. The CD274 - PD-1 pathway is involved in the negative regulation of some immune responses and may play an important role in the regulation of peripheral tolerance.

60533

P07750

NP_068693

Fc Tag

Recombinant Proteins

CHO cells

Immunology

Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 μ g/ml in sterile PBS.

Room Temp

Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.

This recombinant proteins is for research use only.

CD274 antigen

Mus musculus

PD-L1, Programmed Cell Death 1 Ligand Protein 1, PDCD1 Ligand 1, B7-H1, PDL1

Mouse

11230798

Lyophilized

9000-83-3