1- (1-Naftyl) piperazine

1- (1-Naphthyl) piperazine is a 5-HT receptor modulator that acts as both a 5-HT2A receptor antagonist and 5-HT1A receptor agonist, and binds to human 5-HT6 receptor with a Ki of 120 nM. 1- (1-Naphthyl) piperazine partially inhibits forskolin-stimulated adenylate cyclase activity in calf substantia nigra. 1- (1-Naphthyl) piperazine inhibits UV-induced immunosuppression. 1- (1-Naphthyl) piperazine induces S-phase cell cycle delay, apoptosis and increases ROS levels, leading to inhibit MNT-1 cell proliferation. 1- (1-Naphthyl) piperazine can be used for melanoma research[1][2][3][4].

57536-86-4

12352005

H302-H315-H319-H335

5-HT Receptor; Adenylate Cyclase; Apoptosis; Reactive Oxygen Species (ROS)

Apoptosis; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Cancer

C12=C(C=CC=C2N3CCNCC3)C=CC=C1

C14H16N2

212.29

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

[1]Lee M, et al. 1- (1-Naphthyl) piperazine as a novel template for 5-HT6 serotonin receptor ligands. Bioorg Med Chem Lett. 2005 Mar 15;15 (6) :1707-11.|[2]Schoeffter P, et al. Interaction of arylpiperazines with 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors: do discriminatory 5-HT1B receptor ligands exist? Naunyn Schmiedebergs Arch Pharmacol. 1989 Jun;339 (6) :675-83.|[3]Menezes AC, et al. Development and characterization of novel 1- (1-Naphthyl) piperazine-loaded lipid vesicles for prevention of UV-induced skin inflammation. Eur J Pharm Biopharm. 2016 Jul;104:101-9.|[4]Menezes AC, et al. Cytotoxic effect of the serotonergic drug 1- (1-Naphthyl) piperazine against melanoma cells. Toxicol In Vitro. 2018 Mar;47:72-78.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W130288/

Reference compound2

No Development Reported

5-HT6 Receptor