1-Chloormethylpyreen
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
1-Chloromethylpyrene is an alkylating agent that enters the DNA double helix structure through intercalation, forms covalent bonds with electrophilic groups, resulting in DNA cross-linking, thereby inhibiting the proliferation of tumor cells[1].
1086-00-6
12352005
H302+H312+H332, H314
DNA Alkylator/Crosslinker
Cell Cycle/DNA Damage
Cancer-programmed cell death
Cancer
98.0
ClCC1=C(C=C2)C3=C4C2=CC=CC4=CC=C3C=C1
C17H11Cl
250.73
H302+H312+H332, H314
[1]Peck RM, et al., Mixed bifunctionality. 4. Antitumor activity of alkylating derivatives of polycyclic aromatic hydrocarbons as a function of structure and of vehicle. J Med Chem. 1972 Jan;15 (1) :68-70.
Room Temperature
-20°C, 3 years; 4°C, 2 years (Powder)
http://file.medchemexpress.com/batch_PDF/HY-W111005/1-Chloromethylpyrene-SDS-MedChemExpress.pdf
Reference compound1
No Development Reported
Beschrijving
1-Chloromethylpyrene is an alkylating agent that enters the DNA double helix structure through intercalation, forms covalent bonds with electrophilic groups, re
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