10-Deacetyl-7-xylosyl paclitaxel
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
90332-63-1
10-Deacetyl-7-xylosyltaxol, 7-xylosyl-10-deacetylpaclitaxel
C07250-5mg
Bcl-2
Apoptosis
CC1=C2C (C (=O) C3 (C (CC4C (C3C (C (C2 (C) C) (CC1OC (=O) C (C (C5=CC=CC=C5) NC (=O) C6=CC=CC=C6) O) O) OC (=O) C7=CC=CC=C7) (CO4) OC (=O) C) OC8C (C (C (CO8) O) O) O) C) O
C50H57NO17
10-Deacetyl-7-xylosyl paclitaxel (10-Deacetyl-7-xylosyltaxol, 7-xylosyl-10-deacetylpaclitaxel), a derivative of paclitaxel and naturally occurring xyloside isolated from Taxus chinensis, causes significant mitotic arrest in PC-3 cells followed by up-regulating expression of pro-apoptotic Bax and Bad protein, as well as down-regulating expression of anti-apoptotic Bcl-2 and Bcl-XL , which leads to a disturbance of the mitochondrial membrane permeability and to the activation of caspase-9.
3 years -20°C powder
Beschrijving
10-Deacetyl-7-xylosyl paclitaxel Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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