(±) -10-Hydroxycamptothecine (standaard)

(±) -10-Hydroxycamptothecin (Standard) is the analytical standard of (±) -10-Hydroxycamptothecin. This product is intended for research and analytical applications. (±) -10-Hydroxycamptothecin is an indole alkaloid that inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity.

64439-81-2

12352100

Reference Standards; Topoisomerase

Cell Cycle/DNA Damage; Others

Cancer

O=C1C(O)(CC)C2=C(CO1)C(N3CC4=CC5=CC(O)=CC=C5N=C4C3=C2)=O

C20H16N2O5

364.35

[1]Liu SY, et al. Interaction of several nucleoside triphosphate analogues and 10-hydroxycamptothecin with human DNA topoisomerases. Cancer Res. 1989 Mar 15;49 (6) :1366-70.|[2]Ping YH, et al. Anticancer effects of low-dose 10-hydroxycamptothecin in human colon cancer. Oncol Rep. 2006 May;15 (5) :1273-9.|[3]Fan J, et al. Detection of apoptosis exposed to 10-hydroxycamptothecin in T24 human urinary bladder cancer cells. Zhonghua Wai Ke Za Zhi. 1999 Jan;37 (1) :57-9.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N0275R/

Reference Standards