1,1'- (Azodicarbonyl) -dipiperidine

1,1'- (Azodicarbonyl) -dipiperidine (ADDP) can be used in the condensation reaction of alcohols with acidic compounds. 1,1'- (Azodicarbonyl) -dipiperidine can also be used in the synthesis of GPR120 agonists with antidiabetic activity, as well as the synthesis of triple agonists for PPARα, PPARγ, and PPARδ. 1,1'- (Azodicarbonyl) -dipiperidine can be used in metabolic disease research[1][2][3][4].

10465-81-3

ADDP; SR 4077

12352005

H315, H319, H335

Free Fatty Acid Receptor; PPAR

Cell Cycle/DNA Damage; GPCR/G Protein; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Metabolic Disease

98.0

O=C(/N=N/C(N1CCCCC1)=O)N2CCCCC2

C12H20N4O2

252.31

H315, H319, H335

[1]Tsunoda T, et al. 1, 1′- (azodicarbonyl) dipiperidine-tributylphosphine, a new reagent system for mitsunobu reaction[J]. Tetrahedron letters, 1993, 34 (10) : 1639-1642.|[2]Hirose D, et al. Systematic Evaluation of 2-Arylazocarboxylates and 2-Arylazocarboxamides as Mitsunobu Reagents. J Org Chem. 2018 Apr 20;83 (8) :4712-4729.|[3]Zhang X, et al. Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists. Bioorg Med Chem Lett. 2017 Aug 1;27 (15) :3272-3278.|[4]Mogensen JP, et al. Design and synthesis of novel PPARalpha/gamma/delta triple activators using a known PPARalpha/gamma dual activator as structural template. Bioorg Med Chem Lett. 2003 Jan 20;13 (2) :257-60.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-Y1624/1-1-Azodicarbonyl-dipiperidine-SDS-MedChemExpress.pdf

Reference compound1

No Development Reported

PPARα; PPARγ; PPARδ