11-Ketoprogesteron
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
11-Ketoprogesterone (11KP4) is the substrate for CYP17A1 and 11β-HSD2 that could be metabolized to 21-deoxycortisone (21dE) and 21-deoxycortisol (21dF) with glucocorticoid activity[1].
516-15-4
11KP4
12352211
H302, H315, H319, H335
11β-HSD; Cytochrome P450
Metabolic Enzyme/Protease
Cancer-programmed cell death
Cancer
98.44
C[C@@]12[C@]3([H])[C@](CCC1=CC(CC2)=O)([H])[C@@]4([H])[C@](CC3=O)([C@H](CC4)C(C)=O)C
C21H28O3
328.45
H302, H315, H319, H335
[1]van Rooyen D, et al., CYP17A1 exhibits 17αhydroxylase/17,20-lyase activity towards 11β-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathway. J Steroid Biochem Mol Biol. 2020 May;199:105614.
Room Temperature
-20°C, 3 years; 4°C, 2 years (Powder)
http://file.medchemexpress.com/batch_PDF/HY-W342082/11-Ketoprogesterone-SDS-MedChemExpress.pdf
Reference compound1
No Development Reported
Beschrijving
11-Ketoprogesterone (11KP4) is the substrate for CYP17A1 and 11β-HSD2 that could be metabolized to 21-deoxycortisone (21dE) and 21-deoxycortisol (21dF) with glu
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