11beta-Hydroxyprogesteron (standaard)

11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM.

600-57-7

11β-Hydroxyprogesterone (Standard)

12352211

11β-HSD

Metabolic Enzyme/Protease

Cardiovascular Disease

C[C@@]12[C@]3([H])[C@](CCC1=CC(CC2)=O)([H])[C@@]4([H])[C@@](C)([C@@H](C(C)=O)CC4)C[C@@H]3O

C21H30O3

330.47

[1]Rafestin-Oblin ME, et al. 11beta-hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells. Mol Pharmacol. 2002 Dec;62 (6) :1306-13.|[2]Souness GW, et al. 11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid dehydrogenase, possess hypertensinogenic activity in the rat. Hypertension. 1996 Mar;27 (3 Pt 1) :421-5.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N2337R/

Reference Standards