12-Deoxyphorbol 13-isobutyraat

12-Deoxyphorbol 13-isobutyrate (ER272) (DPB), a diterpene, is a PKCα activator. 12-Deoxyphorbol 13-isobutyrate can be isolated from Euphorbia resinifera's latex. 12-Deoxyphorbol 13-isobutyrate facilitates neural stem cells (NSCs) proliferation and activation as well as TGFα release in a reaction dependent on PKCα activation. 12-Deoxyphorbol 13-isobutyrate increases cognitive performance and hippocampal neurogenesis in senescence-accelerated mouse-prone (SAMP8) models. 12-Deoxyphorbol 13-isobutyrate can be used for neurodegenerative diseases research[1][2].

25090-74-8

12352100

PKC

Epigenetics; TGF-beta/Smad

Neurological Disease

CC(C)C(O[C@@]12[C@@]([C@@]3([H])[C@]([C@@H](C2)C)([C@@]4([H])[C@](CC(CO)=C3)(C(C(C)=C4)=O)O)O)([H])C1(C)C)=O

C24H34O6

418.52

[1]Gómez-Oliva R, et al. Rescue of neurogenesis and age-associated cognitive decline in SAMP8 mouse: Role of transforming growth factor-alpha. Aging Cell. 2023 Jun;22 (6) :e13829. |[2]Hammad D, et al. Chemical Components of the Dried Latex of Euphorbia resinifera Berg and Its Medicinal Features. Chem Biodivers. 2025 Jul;22 (7) :e202403067.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N16121/

Natural Products

No Development Reported

PKCα