12-ketochenodeoxycholzuur (standaard)

Afatinib (Standard) is the analytical standard of Afatinib. This product is intended for research and analytical applications. Afatinib (BIBW 2992) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer[1][2][3][4].

2458-08-4

12352211

H315-H319

Autophagy; Reference Standards

Autophagy; Others

Metabolic Disease

C[C@H](CCC(O)=O)[C@H]([C@]12C)CC[C@@]1([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC2=O

C24H38O5

406.56

P264-P280-P302+P352-P305+P351+P338-P362+P364

[1]Sawada, H. et al. Microbial production of chenodeoxycholic acid precursor, 12-ketochenodeoxycholic acid, from dehydrocholic acid. European Journal of Applied Microbiology and Biotechnology, 10 (1–2), 107–112.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W403933R/

Reference Standards