1,2,3,4-Tetrahydro Stauroclosporine

1,2,3,4-Tetrahydrostaurosporine is a derivative of Staurosporine and an inhibitor of mutant EGFR (IC50=74 nM for EGFRT790M). It is selective for EGFRT790M over wild-type EGFR (IC50=390 nM). It also binds to Janus kinase 3 (JAK3).

220038-19-7

AFN-941

12352005

EGFR; JAK

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Others

C[C@@]12[C@H](OC)[C@H](NC)C[C@@H](O1)N3C4=C(C5=C3C6=C(C7=C5C(NC7)=O)C8=CC=CC=C8N62)CCCC4

C28H30N4O3

470.56

[1]Song, et al. Staurosporine scaffold-based rational discovery of the wild-type sparing reversible inhibitors of EGFR T790M gatekeeper mutant in lung cancer with analog-sensitive kinase technology. J. Mol. Recognit. 30 (4) :e2590, (2017) .

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W740378/

Reference compound1

No Development Reported