1,2,3,4,7,8,9-Heptachloordibenzofuran

1,2,3,4,7,8,9-Heptachlorodibenzofuran (1,2,3,4,7,8,9-HpCDF) is a compound that induces the expression of CYP1A1 and CYP1B1 genes in human peripheral blood lymphocytes, while also promoting the expression of the aryl hydrocarbon receptor repressor (AhRR) . 1,2,3,4,7,8,9-Heptachlorodibenzofuran can increase ethoxyresorufin-O-deethylase (EROD) activity in isolated human peripheral blood lymphocytes in a concentration-dependent manner, which serves as a marker of CYP1A1 activity. Furthermore, 1,2,3,4,7,8,9-Heptachlorodibenzofuran exhibits immunosuppressive effects by reducing the number of splenic plaque-forming cells in mice and increasing aryl hydrocarbon hydroxylase (AHH) activity in liver microsomes of mice injected with sheep red blood cells. 1,2,3,4,7,8,9-Heptachlorodibenzofuran can be used in research in the fields of immunology, metabolic diseases, and environmental toxicology[1][2][3][4].

55673-89-7

1,2,3,4,7,8,9-HpCDF

12352005

H300-H310-H330-H410

Aryl Hydrocarbon Receptor; Cytochrome P450

Immunology/Inflammation; Metabolic Enzyme/Protease

Metabolic Disease; Inflammation/Immunology

C1=C2C(=C(C(=C1Cl)Cl)Cl)C3=C(O2)C(=C(C(=C3Cl)Cl)Cl)Cl

C12HCl7O

409.31

P260-P262-P264-P270-P271-P273-P280-P284-P302+P352-P304+P340-P330-P361+P364-P391-P403+P233-P405-P501

[1]Dickerson R, et al. The structure-dependent effects of heptachlorodibenzofuran isomers in male C57BL/6 mice: immunotoxicity and monooxygenase enzyme induction. Fundam Appl Toxicol. 1990 Aug;15 (2) :298-307.|[2]van Ede KI, et al. Differential relative effect potencies of some dioxin-like compounds in human peripheral blood lymphocytes and murine splenic cells. Toxicol Lett. 2014 Apr 7;226 (1) :43-52.|[3]Hu SW, et al. PCDD/Fs levels in indoor environments and blood of workers of three municipal waste incinerators in Taiwan. Chemosphere. 2004 Apr;55 (4) :611-20.|[4]Tawara K, et al. Effects of maternal dioxin exposure on newborn size at birth among Japanese mother-infant pairs. Environ Health Prev Med. 2009 Mar;14 (2) :88-95.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W517092/

Reference compound1

No Development Reported