(123B9) 2-L2-PTX

(123B9) 2-L2-PTX is an EphA2-agonistic peptide-drug conjugate (PDC). (123B9) 2-L2-PTX consists of a dimeric 123B9 and Paclitaxel (HY-B0015). (123B9) 2-L2-PTX significantly reduces circulating tumor cells and inhibits lung tumor metastasis in breast-cancer-Metastasis mice model. (123B9) 2-L2-PTX can be used for cancers research, such as melanomas and ovarian and breast cancers[1].

12352209

Ephrin Receptor; Peptide-Drug Conjugates (PDCs)

Antibody-drug Conjugate/ADC Related; Protein Tyrosine Kinase/RTK

Cancer

ClC1=C(C=CC(OCC(NC(C(N[C@H](C(NC(C(N2CCCC2C(NC(C(N[C@H](C(NC(C(C)C)C(N3CCC4([C@H](NC([C@@H]34)=O)C(NC(C(N[C@H](C(NCC(NCCCC[C@@H](C(NCC(N[C@@H](C(NCC(O)=O)=O)CCCCNC(CCCC5N=NN(CCCCCC(O[C@@H](C(O[C@@H]6C(C)=C([C@H]7OC(C)=O)C(C)(C)[C@@]([C@@H](OC(C8=CC=CC=C8)=O)[C@]9([H])[C@@]%10(OC(C)=O)[C@H](OC%10)C[C@H](O)[C@](C)9C7=O)(O)C6)=O)[C@@H](NC(C%11=CC=CC=C%11)=O)C%12=CC=CC=C%12)=O)C5)=O)=O)=O)NC(CNC([C@@H](NC(C(NC([C@H]%13NC([C@H]%14N(CCC%13%14CCC)C(C(C(C)C)NC([C@@H](NC([C@@H](NC(C%15CCCN%15C(C(NC([C@@H](NC(C(NC(COC%16=CC(Cl)=C(C=C%16)F)=O)CO)=O)C)=O)CC%17=CC=C(C=C%17)O)=O)=O)CC(O)=O)=O)CO)=O)=O)=O)=O)CCO)=O)CO)=O)=O)=O)=O)CO)=O)CO)=O)CCC)=O)=O)CO)=O)CC(O)=O)=O)=O)CC%18=CC=C(C=C%18)O)=O)C)=O)CO)=O)=C1)F

C192H254Cl2F2N34O63

4155.16

[1]Salem AF, et al. Reduction of Circulating Cancer Cells and Metastases in Breast-Cancer Models by a Potent EphA2-Agonistic Peptide-Drug Conjugate. J Med Chem. 2018 Mar 8;61 (5) :2052-2061.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11018/

Peptides

No Development Reported

EphA