(123B9) 2-Motief

(123B9) 2-Motif is a selective EphA2 receptor agonist (Kd=4.9 μM) that does not bind to EphA4. (123B9) 2-Motif works by inducing EphA2 receptor phosphorylation and oligomerization, thereby promoting receptor activation and internalization. (123B9) 2-Motif is primarily used in targeted drug delivery studies for cancers that overexpress EphA2, such as breast cancer, to reduce circulating tumor cells and inhibit metastasis[1].

12352209

Ephrin Receptor

Protein Tyrosine Kinase/RTK

Cancer

C#CCCCC(NCCCC[C@@H](C(NCC(N)=O)=O)NC(CNC([C@@H](NC(CNC([C@@H](NC(C(NC([C@]1(NC([C@@H]2C1CCN2C([C@H](C(C)C)NC([C@@H](NC([C@@H](NC(C3CC=CN3C([C@H](CC4=CC=C(O)C=C4)NC([C@@H](NC([C@@H](NC(COC5=CC(Cl)=C(C=C5)F)=O)CO)=O)C)=O)=O)=O)CC(O)=O)=O)CO)=O)=O)=O)CCCC)=O)CCO)=O)CO)=O)=O)CCCCNC(CNC([C@@H](NC([C@@H](NC([C@H](CCCC)NC([C@H]6N(CCC6)C(C(C(C)C)NC(/C(CO)=N/C([C@@H](NC(C7CCCN7C([C@H](CC8=CC=C(O)C=C8)NC([C@@H](NC([C@@H](NC(COC9=CC(Cl)=C(C=C9)F)=O)CO)=O)C)=O)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)CCO)=O)CO)=O)=O)=O)=O)=O

C142H197Cl2F2N31O47

3199.17

[1]Salem AF, et al. Reduction of Circulating Cancer Cells and Metastases in Breast-Cancer Models by a Potent EphA2-Agonistic Peptide-Drug Conjugate. J Med Chem. 2018 Mar 8;61 (5) :2052-2061.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11015/

Peptides

No Development Reported

EphA