19

IL-19 belongs to the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. Preliminary data suggests that IL-19 is a proinflammatory cytokine because it up-regulates IL-6 and TNF-alpha and induces apoptosis through TNF-alpha. IL-19 signals through the type I IL-20R. Human and murine IL-19 share 71% amino acid sequence identity. Recombinant human IL-19 is a 17.9 kDa protein containing 153 amino acid residues. In solution IL-19 exists predominantly as a non-disulfide-linked dimer.

IL19; MDA1; NG.1; ZMDA1; IL-10C

29949

Q9UHD0

NP_715639.1

NM_153758

1q32.2

Human

Human

MLRRCLISTD MHHIEESFQE IKRAIQAKDT FPNVTILSTL ETLQIIKPLD VCCVTKNLLA FYVDRVFKDH QEPNPKILRK ISSIANSFLY MQKTLRQCQE QRQCHCRQEA TNATRVIHDN YDQLEVHAAA IKSLGELDVF LAWINKNHEV MSSA

< 0.1 ng/µg of protein (< 1EU/µg)

> 99% by SDS-PAGE & HPLC analysis

Determined by its ability to activate STAT following receptor-ligand interaction.

153

Lyophilized

17.9 kDa

E. coli