19-Nor-22-oxa-1a,25 (OH) 2-VD3

19-Nor-22-oxa-1a,25 (OH) 2-VD3 is a vitamin D₃ analogue. 19-Nor-22-oxa-1a,25 (OH) 2-VD3 has an extremely low affinity for the vitamin D receptor (VDR) and hardly binds to the vitamin D binding protein (DBP) . 19-Nor-22-oxa-1a,25 (OH) 2-VD3 can effectively induce the differentiation of HL-60 cells and cause G₀-G₁ phase cell cycle arrest. 19-Nor-22-oxa-1a,25 (OH) 2-VD3 can be used to study diseases such as excessive hyperparathyroidism[1].

284041-36-7

12352005

VD/VDR

Vitamin D Related/Nuclear Receptor

Metabolism-sugar/lipid metabolism

Endocrinology

C[C@@]12[C@](CC[C@]2([H])[C@H](C)OCCC(C)(O)C)([H])/C(CCC1)=C/C=C3C[C@H](C[C@@H](C\3)O)O

C25H42O4

406.60

[1]Kubodera NK, et al. Biological activities of 19-nor-1alpha,25-dihydroxyvitamin D3 analogs singly dehydroxylated at the C-1 or C-3 position of the A-ring. Curr Pharm Des. 2000 May;6 (7) :791-801.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-180503/

Reference compound1

No Development Reported