(1S,9R) -Ac-Exatecan
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
(1S,9R) -Ac-Exatecan is an intermediate for the synthesis of Exatecan. Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM).
12352005
Drug Intermediate
Others
Cancer
O=C1OCC(C(N2C(C3=NC4=CC(F)=C(C5=C4C([C@H](CC5)NC(C)=O)=C3C2)C)=C6)=O)=C6[C@@]1(CC)O
C26H24FN3O5
477.48
[1]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86 (8) :776-82.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-43565C/
Reference compound1
No Development Reported
Beschrijving
(1S,9R) -Ac-Exatecan is an intermediate for the synthesis of Exatecan. Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an
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