2-Aminoimidazool (standaard)

2-Aminoimidazole is a potent antibiofilm agent that can be used as an adjuvant to antimicrobial. 2-aminoimidazoles disrupts the ability of bacteria to protect themselves by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. 2-Aminoimidazole is also a weak noncompetitive inhibitor of human arginase I with a Ki of 3.6 mM[1][2][3].

7720-39-0

12352005

Arginase; Bacterial

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease

Infection

NC1=NC=CN1

C3H5N3

83.09

[1]Thompson RJ, et, al. Identification of BfmR, a response regulator involved in biofilm development, as a target for a 2-Aminoimidazole-based antibiofilm agent. Biochemistry. 2012 Dec 11;51 (49) :9776-8.|[2]Jacobs L, et, al. 2-Aminoimidazoles as potent inhibitors of contaminating brewery biofilms. Biofouling. 2021 Feb 11;1-17.|[3]Ilies M, et, al. 2-aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I. J Med Chem. 2010 May 27;53 (10) :4266-76.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W062216R/

Reference Standards