2′-Deoxyadenosine 5′-monofosfaat (dinatrium) (standaard)

Halofuginone (Standard) is the analytical standard of Halofuginone. This product is intended for research and analytical applications. Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM[1][2]. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity[3][4]. Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects[5].

2922-74-9

12352005

Endogenous Metabolite; Reference Standards

Metabolic Enzyme/Protease; Others

Metabolic Disease

O[C@H]1C[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1COP(O[Na])(O[Na])=O

C10H12N5Na2O6P

375.19

[1]Katsuya Narumi, et al. Mutual role of ecto-5'-nucleotidase/CD73 and concentrative nucleoside transporter 3 in the intestinal uptake of dAMP. PLoS One. 2019 Oct 21;14 (10) :e0223892.|[2]V Duarte, et al. Insertion of dGMP and dAMP during in vitro DNA synthesis opposite an oxidized form of 7,8-dihydro-8-oxoguanine. Nucleic Acids Res. 1999 Jan 15;27 (2) :496-502.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W105272R/

Reference Standards