2'-Deoxyguanosinemonohydraat-13C5

2'-Deoxyguanosine monohydrate-13C5 is the 13C-labeled 2'-Deoxyguanosine monohydrate. 2'-Deoxyguanosine monohydrate is a nucleoside composed of guanine and deoxyribose, and is one of the basic building blocks of DNA. In the oxidation reaction mediated by singlet oxygen 1O2, the guanine base of 2'-Deoxyguanosine is easily oxidized to generate two major products, 4,8-dihydro-4-hydroxy-8-oxodG and 7,8-dihydro-8-oxodG. The oxidation products of 2'-Deoxyguanosine monohydrate may participate in DNA damage, which may affect gene expression or induce cancer[1].

12352005

Endogenous Metabolite; Isotope-Labeled Compounds

Metabolic Enzyme/Protease; Others

Metabolic Disease

O=C1C2=C(N=C(N1)N)N([13C@]3[13C][13C@@]([13C@](O3)[13C]O)O)C=N2.O

C5 13C5H8N5O5

283.16

[1]Ravanat JL, et al. Reaction of singlet oxygen with 2'-deoxyguanosine and DNA. Isolation and characterization of the main oxidation products. Chem Res Toxicol. 1995 Apr-May;8 (3) :379-88.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W768213/

Isotope-Labeled Compounds

No Development Reported