2-Deoxyuridine-1,2,3,4,5-13C5

2-Deoxyuridine-1,2,3,4,5-13C5 is the 13C-labeled 2'-Deoxyuridine. 2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD)[2][3].

478510-94-0

12352005

Endogenous Metabolite; Isotope-Labeled Compounds; Thymidylate Synthase

Apoptosis; Metabolic Enzyme/Protease; Others

COVID-19-immunoregulation

Infection

O[13C@H]1[13CH2][13C@@H](O[13C@@H]1[13CH2]O)N(C(N2)=O)C=CC2=O

C4 13C5H12N2O5

233.17

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W778990/

Isotope-Labeled Compounds

No Development Reported