2'-Deoxyuridine 5'-monofosfaat
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
2'-Deoxyuridine 5'-monophosphate (dUMP) is a deoxynucleotide that is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS) . dTMP is a nucleotide required for DNA synthesis[1].
964-26-1
DUMP
12352005
H302-H315-H319-H335
Endogenous Metabolite
Metabolic Enzyme/Protease
Metabolism-protein/nucleotide metabolism
Infection; Metabolic Disease
O[C@H]1C[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1COP(O)(O)=O
C9H13N2O8P
308.18
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
[1]Zachary Newby, et al. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP) -binding Tyr-261. Biochemistry. 2006 Jun 20;45 (24) :7415-28.|[2]Skouloubris S, et al. Targeting of Helicobacter pylori thymidylate synthase ThyX by non-mitotoxic hydroxy-naphthoquinones. Open Biol. 2015 Jun;5 (6) :150015.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W394006/
Reference compound1
No Development Reported
Beschrijving
2'-Deoxyuridine 5'-monophosphate (dUMP) is a deoxynucleotide that is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme t
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