2-Guanidinobezimidazool

2-Guanidinobezimidazole (2GBI) is a selective agonist of NLRP3, with a KD value of 1.29 μM to His-GFP-NLRP3. 2-Guanidinobezimidazole binds directly to the LRR domain of NLRP3, promoting inflammasome assembly and activation. 2-Guanidinobezimidazole promotes anti-tumor immunity, inhibits tumor growth, and overcome immune checkpoint blockade (ICB) resistance[1].

5418-95-1

2GBI

12352005

H302, H315, H319, H335

NOD-like Receptor (NLR)

Immunology/Inflammation

Cancer-programmed cell death

Cancer

95.74

N/C(N)=N/C1=NC2=CC=CC=C2N1

C8H9N5

175.19

H302, H315, H319, H335

[1]Liu X, et al. A small molecule directly targets NLRP3 to promote inflammasome activation and antitumor immunity. Cell Death Dis. 2025 Apr 4;16 (1) :252.

Room Temperature

4°C (Powder, protect from light)

http://file.medchemexpress.com/batch_PDF/HY-W158030/2-Guanidinobezimidazole-SDS-MedChemExpress.pdf

Reference compound2

No Development Reported