2-HydroxyImiquimod

2-Hydroxy Imiquimod (R-842), a hydroxylated metabolite of Imiquimod , is an immunomodulating agent. 2-Hydroxy Imiquimod can induce IFN-α, TNF-α, IL-1, IL-6 and IL-8 in human blood cells. 2-Hydroxy Imiquimod exhibits antivirus and antitumor activities. 2-Hydroxy Imiquimod can be used for the researches of cancer, infection and immunology[1][2].

112668-45-8

R-842

12352005

Drug Metabolite; IFNAR; Interleukin Related; TNF Receptor

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease

COVID-19-anti-virus

Cancer; Infection; Inflammation/Immunology

OC(C)(CN1C=NC2=C1C3=C(C=CC=C3)N=C2N)C

C14H16N4O

256.30

[1]Weeks CE, et al. Induction of interferon and other cytokines by imiquimod and its hydroxylated metabolite R-842 in human blood cells in vitro. J Interferon Res. 1994 Apr;14 (2) :81-5.|[2]Imbertson LM, et al. Cytokine induction in hairless mouse and rat skin after topical application of the immune response modifiers imiquimod and S-28463. J Invest Dermatol. 1998 May;110 (5) :734-9.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W744192/

Reference compound1

No Development Reported

IL-1; IL-6; IL-8