2-Linoleoyl glycerol-d5

2-Linoleoyl glycerol-d5 (2-Monolinolein-d5; 2-Monolinoleoylglycerol-d5) is the deuterium labeled 2-Linoleoyl glycerol. 2-Linoleoyl glycerol (2-Monolinolein; 2-Monolinoleoylglycerol) is a monoacylglycerol that is an antagonist and partial agonist at the type 1 cannabinoid CB1 receptor. The potency of 2-Linoleoyl glycerol can be enhanced by JZL195 (HY-15250), an inhibitor of FAAH and MAGL, and inhibited by the CB1 antagonist AM251 (HY-15443) and Cannabidiol. As a CB1 antagonist, 2-Linoleoyl glycerol does not enhance, but only attenuates, the activity of the CB1/CB2 receptor ligands cannabinoids (AEA) and 2-arachidonoylglycerol (2-AG)[2].

2-Monolinolein-d5; 2-Monolinoleoylglycerol-d5

12352211

Cannabinoid Receptor; Isotope-Labeled Compounds

GPCR/G Protein; Neuronal Signaling; Others

Neurological Disease

O=C(OC([2H])(C([2H])(O)[2H])C([2H])(O)[2H])CCCCCCC/C=C\C/C=C\CCCCC

C21H33D5O4

359.55

[1]Lu L, et al. 2-Linoleoylglycerol is a partial agonist of the human cannabinoid type 1 receptor that can suppress 2-arachidonolyglycerol and anandamide activity[J]. Cannabis and cannabinoid research, 2019, 4 (4) : 231-239.|[2]Sugiura T, et al. 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastomax glioma hybrid NG108-15 cells[J]. Biochemical and biophysical research communications, 1996, 229 (1) : 58-64.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W770198/

Isotope-Labeled Compounds

No Development Reported