2-Methylthiofenothiazine

2-Methylthiophenothiazine (compound 17) is a precursor of tubulin inhibitor with potential anticancer activity and can inhibit tubulin aggregation[1][2].

7643-08-5

12352005

H302, H317, H373, H410

Microtubule/Tubulin

Cell Cycle/DNA Damage; Cytoskeleton

Cancer

99.77

CSC1=CC(NC2=CC=CC=C2S3)=C3C=C1

C13H11NS2

245.36

H302, H317, H373, H410

[1]Prinz H, et al. N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2011 Jun 23;54 (12) :4247-63.|[2]Glass-Marmor L, et al. Calmodulin antagonists decrease glucose 1,6-bisphosphate, fructose 1,6-bisphosphate, ATP and viability of melanoma cells. Eur J Pharmacol. 1996 Oct 17;313 (3) :265-71.

Room Temperature

Store at room temperature 3 years

http://file.medchemexpress.com/batch_PDF/HY-W011996/2-Methylthiophenothiazine-SDS-MedChemExpress.pdf

Reference compound1

No Development Reported