2'-O-methylcytidine (standaard)

2'-O-Methylcytidine is an orally active 2'-substituted nucleoside as a inhibitor of HCV replication with antiviral activity. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B) -catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate[1][2][3].

2140-72-9

12352005

H302, H315, H319, H335

DNA/RNA Synthesis; HCV

Anti-infection; Cell Cycle/DNA Damage

Infection

99.71

O[C@H]1[C@@H](OC)[C@H](N2C(N=C(N)C=C2)=O)O[C@@H]1CO

C10H15N3O5

257.25

H302, H315, H319, H335

[1]Steven S Carroll, et al. Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs. J Biol Chem. 2003 Apr 4;278 (14) :11979-84|[2]Hingerty B, et al. The crystal and molecular structure of 2'-O-methylcytidine[J]. Acta Crystallographica Section B: Structural Crystallography and Crystal Chemistry, 1977, 33 (5) : 1349-1356.|[3]Del Vecchio AM, et al. Small molecule and biologic inhibitors of hepatitis C virus: a symbiotic approach. Mini Rev Med Chem. 2006 Nov;6 (11) :1263-8.

Blue Ice

4°C, sealed storage, away from light and moisture

http://file.medchemexpress.com/batch_PDF/HY-W011834R/2-O-Methylcytidine-Standard-SDS-MedChemExpress.pdf

Reference Standards