2-Oleoylglycerol-d5

2-Oleoylglycerol-d5 (2-OG-d5) is the deuterium labeled 2-Oleoylglycerol. 2-Oleoylglycerol (2-OG) is a lipid found in the diet. It is a GPR119 agonist, with an EC50 value of 2.5 μM in activating hGPR119 in transiently transfected COS-7 cells. 2-Oleoylglycerol enhances the inflammatory response of macrophages and promotes fibrosis by activating the GPR119/TAK1/NF-κB/TGF-β1 signaling pathway. It also stimulates glucagon-like peptide 1 (GLP-1) secretion in vivo. 2-Oleoylglycerol is expected to be used in the research of non-alcoholic steatohepatitis (NASH)[2][3].

946524-37-4

2-OG-d5

12352211

GLP Receptor; GPR119; Isotope-Labeled Compounds; NF-κB; TGF-beta/Smad

GPCR/G Protein; Neuronal Signaling; NF-κB; Others; Stem Cell/Wnt; TGF-beta/Smad

Metabolism-sugar/lipid metabolism

Metabolic Disease

O=C(CCCCCCC/C=C\CCCCCCCC)OC([2H])(C([2H])(O)[2H])C([2H])(O)[2H]

C21H35D5O4

361.57

[1]Hansen KB, et, al. 2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans. J Clin Endocrinol Metab. 2011 Sep;96 (9) :E1409-17.|[2]Ghafouri N, et, al. Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol. Br J Pharmacol. 2004 Nov;143 (6) :774-84.|[3]Yang M, et al. Western diet contributes to the pathogenesis of non-alcoholic steatohepatitis in male mice via remodeling gut microbiota and increasing production of 2-oleoylglycerol. Nat Commun. 2023 Jan 16;14 (1) :228.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W701772/

Isotope-Labeled Compounds

No Development Reported