2,3-Dinor-8-isoprostaglandine F 2α

2,3-Dinor-8-iso prostaglandin F₂α (2,3-Dinor-8-isoPGF2α) is the major β-oxidation metabolite of 8-iso-prostaglandin F₂α. 2,3-Dinor-8-iso prostaglandin F₂α serves as a biomarker to evaluate the in vivo production of 8-iso-prostaglandin F₂α and the level of lipid peroxidation. 2,3-Dinor-8-iso prostaglandin F₂α is promising for research of oxidative stress-related diseases such as arteriosclerosis and diabetes[1][2][3].

221664-05-7

2,3-Dinor-8-isoPGF2α

12352211

H225-H319-H336

Drug Metabolite

Metabolic Enzyme/Protease

Metabolic Disease

OC(C/C=C\C[C@H]1[C@H]([C@@H](C[C@@H]1O)O)/C=C/[C@@H](O)CCCCC)=O

C18H30O5

326.43

P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P304+P340-P370+P378-P405-P501

[1]Liang Y, et al. Quantification of 8-iso-prostaglandin-F (2alpha) and 2,3-dinor-8-iso-prostaglandin-F (2alpha) in human urine using liquid chromatography-tandem mass spectrometry. Free Radic Biol Med. 2003 Feb 15;34 (4) :409-18.|[2]Chiabrando C, et al. Identification and measurement of endogenous beta-oxidation metabolites of 8-epi-Prostaglandin F2alpha. J Biol Chem. 1999 Jan 15;274 (3) :1313-9.|[3]Roberts LJ 2nd, et al. Identification of the major urinary metabolite of the F2-isoprostane 8-iso-prostaglandin F2alpha in humans. J Biol Chem. 1996 Aug 23;271 (34) :20617-20.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W353470/

Reference compound2

No Development Reported