24,25-Epoxycholesterol

24,25-Epoxycholesterol is an oxysterol agonist of the liver X receptor that can inhibit the activity of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase) in liver cells. 24,25-Epoxycholesterol regulates cholesterol metabolism in the liver[1].

72542-49-5

12352211

H302, H315, H319, H335

HMG-CoA Reductase (HMGCR) ; LXR

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Metabolic Disease

99.80

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC3C(C)(O3)C)([H])[C@@]4([H])[C@@](CC1)([H])[C@@]5(C(C[C@H](CC5)O)=CC4)C

C27H44O2

400.64

H302, H315, H319, H335

[1]Andrew J Brown, et al. 24 (S),25-epoxycholesterol: a messenger for cholesterol homeostasis. Int J Biochem Cell Biol. 2009 Apr;41 (4) :744-7.

Blue Ice

-20°C, 3 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-W414823/24-25-Epoxycholesterol-SDS-MedChemExpress.pdf

Reference compound1

No Development Reported