2,5-dimethylcyclohexanol

2,5-Dimethylcyclohexanol, a volatile organic compound, is a fatty acid that can be isolated from Amphora sp.. 2,5-Dimethylcyclohexanol has significant antineoplastic and antiviral activities with inhibition of SARS-CoV-2 Mpro. 2,5-Dimethylcyclohexanol also has potent antifungal activity against Pseudogymnoascus destructans. 2,5-Dimethylcyclohexanol compromises cell wall and membrane integrity while perturbing energy metabolism, increases the levels of ROS, ATP, Superoxide anion and GSH, and decreases CAT and SOD activities. And 2,5-Dimethylcyclohexanol alters virulence ribosomal genes expression, and disrupts the MAPK signaling pathways, inducing fungal cell apoptosis[1][2][3].

3809-32-3

12352211

H227-H302

Apoptosis; ATP Synthase; Fungal; Glutathione Peroxidase; p38 MAPK; Reactive Oxygen Species (ROS) ; SARS-CoV; SOD; Virus Protease

Anti-infection; Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB

Cancer; Infection

CC1CCC(C)C(C1)O

C8H16O

128.21

P210-P264-P270-P280-P330-P370+P378-P403-P501

[1]Khumaidi A, et al. Fatty acid profile and in silico pharmacological study of diatom Amphora sp[J]. Aquaculture, Aquarium, Conservation & Legislation, 2020, 13 (4) : 2050-2060.|[2]Huang Z, et al. Mechanisms of volatile organic compounds from bat cave environments against Pseudogymnoascus destructans in vitro. Appl Environ Microbiol. 2025 Nov 13:e0118725. |[3]Shehzadi S, et al. Antiviral COVID-19 protein and molecular docking: In silico characterization of various antiviral compounds extracted from Arisaema jacquemontii Blume. Front Public Health. 2022 Sep 23;10:964741.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W160358/

Reference compound2

Phase 1