(2S,4R) -Teneligliptine

(2S,4R) -Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4) . (2S,4R) -Teneligliptin increases the plasma concentration of active glucagon-like peptide-1 (GLP-1), which promotes insulin secretion in response to elevated blood glucose levels, exerting hypoglycemic activity. (2S,4R) -Teneligliptin is promising for research of type 2 diabetes[1].

1404559-15-4

12352005

H302-H315-H319-H335

Dipeptidyl Peptidase

Metabolic Enzyme/Protease

Neuroscience-Neuromodulation

Metabolic Disease

97.70

CC1=NN(C2=CC=CC=C2)C(N3CCN([C@@H]4C[C@@H](C(N5CSCC5)=O)NC4)CC3)=C1

C22H30N6OS

426.58

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

[1]Yoshida T, et al. Discovery and preclinical profile of teneligliptin (3-[ (2S, 4S) -4-[4- (3-methyl-1-phenyl-1H-pyrazol-5-yl) piperazin-1-yl] pyrrolidin-2-ylcarbonyl] thiazolidine) : a highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes[J]. Bioorganic & medicinal chemistry, 2012, 20 (19) : 5705-5719.

Room Temperature

4°C (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-I0786/

Reference compound2

No Development Reported