(2S,4S) -Argatroban

(2S,4S) -Argatroban (Compound 1c) is human thrombin inhibitor with a Ki of 280 μM[1].

189264-03-7

(2S,4S) -MD-805; (2S,4S) -MCI-9038

12352005

H302-H315-H319-H335

Thrombin

Metabolic Enzyme/Protease

Cardiovascular Disease

S(N[C@H](C(=O)N1[C@H](C(O)=O)C[C@@H](C)CC1)CCCNC(=N)N)(=O)(=O)C2=C3C(=CC=C2)CC(C)CN3

C23H36N6O5S

508.64

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

[1]Jones-Hertzog DK, et al. Binding affinities for sulfonamide inhibitors with human thrombin using Monte Carlo simulations with a linear response method. J Med Chem. 1997 May 9;40 (10) :1539-49.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B0375B/

Reference compound1

No Development Reported