3- (4-Hydroxy-1-oxoisoindoline-2-yl) piperidine-2,6-dion (standaard)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
3- (4-Hydroxy-1-oxoisoindolin-2-yl) piperidine-2,6-dione (Standard) is the analytical standard of 3- (4-Hydroxy-1-oxoisoindolin-2-yl) piperidine-2,6-dione. This product is intended for research and analytical applications. Lenalidomide-4-OH is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-OH can be connected to the ligand for protein by a linker to form PROTAC.
1061604-41-8
12352005
Ligands for E3 Ligase
PROTAC
Cancer
O=C(C(N(CC1=C2C=CC=C1O)C2=O)CC3)NC3=O
C13H12N2O4
260.25
[1]Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W076696R/
Reference Standards
Beschrijving
3- (4-Hydroxy-1-oxoisoindolin-2-yl) piperidine-2,6-dione (Standard) is the analytical standard of 3- (4-Hydroxy-1-oxoisoindolin-2-yl) piperidine-2,6-dione. This
Specificaties
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