3-Acetyl-7-Hydroxycumarine

3-Acetyl-7-Hydroxycoumarin (Compound 2) is a high selective 17-beta-hydroxysteroid dehydrogenase type 1 (17β-HSD1) inhibitor. 3-Acetyl-7-Hydroxycoumarin shows a significant improvement of the inhibitory potency, with 57% inhibition of 17β-HSD1 at 6 μM. 3-Acetyl-7-Hydroxycoumarin is promising for research of hormone-dependent diseases, such as breast cancer and endometriosis[1].

10441-27-7

12352005

H302-H315-H319-H335

17β-HSD

Metabolic Enzyme/Protease

Cancer; Endocrinology

CC(=O)C1=CC2=C(C=C(C=C2)O)OC1=O

C11H8O4

204.18

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

[1]Starcević S, et al. Synthesis and biological evaluation of (6- and 7-phenyl) coumarin derivatives as selective nonsteroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1. J Med Chem. 2011 Jan 13;54 (1) :248-61.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W267205/

Reference compound1

No Development Reported