3-epideoxycholzuur

3-Epideoxycholic acid is the microbial metabolite of Deoxycholic acid. 3-Epideoxycholic acid targets FXR of dendritic cells, reduces their immunostimulatory properties, promotes the generation of Treg cells, and exhibits anti-inflammatory activity. 3-Epideoxycholic acid promotes the growth of bacteria Bacteroides[1][2].

570-63-8

12352211

H302, H315, H319, H335

Endogenous Metabolite; FXR

Metabolic Enzyme/Protease

COVID-19-immunoregulation

Inflammation/Immunology

10mM

99.90

DMSO : 250 mg/mL (ultrasonic)

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(O)=O)([H])[C@@]3([H])[C@@](C[C@@H]1O)([H])[C@@]4([C@](C[C@H](CC4)O)([H])CC3)C

C24H40O4

392.57

H302, H315, H319, H335

[1]Campbell C, et al., Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells. Nature. 2020 May;581 (7809) :475-479. |[2]Devlin AS, et al., A biosynthetic pathway for a prominent class of microbiota-derived bile acids. Nat Chem Biol. 2015 Sep;11 (9) :685-90.

Blue Ice

-20°C, 3 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-48814/3-Epideoxycholic-acid-SDS-MedChemExpress.pdf

Reference compound1

No Development Reported