3-Hydroxy-2-pyron
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
3-Hydroxy-2-pyrone (Compound 12d) is a metalloenzyme inhibitor. 3-Hydroxy-2-pyrone shows an inhibition rate of approximately 50% for matrix metalloproteinases (MMP) and the inhibition rate for non-heme iron enzyme 5-lipoxygenase (5-LOX) was over 70% at 1 mM. 3-Hydroxy-2-pyrone also has certain inhibitory activity against copper-dependent enzyme tyrosinase. 3-Hydroxy-2-pyrone can be used for the research of cancer, infection and inflammation[1].
496-64-0
12352005
H302, H315, H319, H335
Lipoxygenase; MMP; Tyrosinase
Metabolic Enzyme/Protease
Cancer; Infection; Inflammation/Immunology
99.61
O=C1OC=CC=C1O
C5H4O3
112.08
H302, H315, H319, H335
[1]Jacobsen JA, et al. Identifying chelators for metalloprotein inhibitors using a fragment-based approach. J Med Chem. 2011 Jan 27;54 (2) :591-602.
Room Temperature
Store at room temperature 3 years
http://file.medchemexpress.com/batch_PDF/HY-W041193/3-Hydroxy-2-pyrone-SDS-MedChemExpress.pdf
Reference compound2
No Development Reported
Beschrijving
3-Hydroxy-2-pyrone (Compound 12d) is a metalloenzyme inhibitor. 3-Hydroxy-2-pyrone shows an inhibition rate of approximately 50% for matrix metalloproteinases (
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