3-Methylchinoline

3-Methylquinoline is a selective cytochrome P450 (CYP1A2) inhibitor with an IC50 of 13 μM. 3-Methylquinoline can reduce the metabolic clearance of CYP1A2 substrate drugs. 3-Methylquinoline can inhibit the activation of carcinogenic precursors[1].

612-58-8

12352005

H312+H332, H315, H318, H335, H351

Cytochrome P450

Metabolic Enzyme/Protease

Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease

98.83

CC1=CN=C2C=CC=CC2=C1

C10H9N

143.19

H312+H332, H315, H318, H335, H351

[1]Korhonen LE, et al. Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors. J Med Chem. 2005 Jun 2;48 (11) :3808-15.

Room Temperature

Store at room temperature 3 years

http://file.medchemexpress.com/batch_PDF/HY-W015697/

Reference compound2

No Development Reported

CYP1