3-Methylindool-2-carbonzuur

3-Methylthiophene-2-carboxylic acid (compound 3) is a potent Pseudomonas quinolone signal system protein E (PqsE) inhibitor with a Kd of 19.6 µM and an IC50 of 40 µM. 3-Methylthiophene-2-carboxylic acid binds to the active center of PqsE and shows inhibition of the thioesterase activity. Methylthiophene-2-carboxylic acid can permeate into P. aeruginosa and affect 2,4-dihydroxyquinoline (DHQ) levels to a similar extent as deletion of the PqsE gene. 3-Methylthiophene-2-carboxylic acid can be used for cystic fibrosis research[1].

23806-24-8

12352005

H302, H315, H319, H335

Bacterial

Anti-infection

Inflammation/Immunology

99.93

CC(C=CS1)=C1C(O)=O

C6H6O2S

142.18

H302, H315, H319, H335

[1]Zender M, et al. Dissecting the Multiple Roles of PqsE in Pseudomonas aeruginosa Virulence by Discovery of Small Tool Compounds. ACS Chem Biol. 2016 Jun 17;11 (6) :1755-63.

Room Temperature

4°C (Powder, protect from light)

http://file.medchemexpress.com/batch_PDF/HY-W004782/3-Methylthiophene-2-carboxylic-acid-SDS-MedChemExpress.pdf

Reference compound1

No Development Reported