3,4-Dihydroxyamfetamine (hydrochloride)

3,4-Dihydroxyamphetamine (α-Methyldopamine) (hydrochloride) is a secondary metabolite of 3,4-Methylenedioxymethamphetamine (MDMA) . 3, 4-dihydroxyamphetamine (hydrochloride) is cytotoxic to rat hepatocytes. 3, 4-dihydroxyamphetamine (hydrochloride) is also used in the study of high blood pressure[1][2][3].

828-06-8

α-Methyldopamine (hydrochloride) ; α-MeDA (hydrochloride)

12352005

H302-H315-H319-H335

Drug Metabolite

Metabolic Enzyme/Protease

Neurological Disease; Cardiovascular Disease

CC(N)CC1=CC(O)=C(O)C=C1.Cl

C9H14ClNO2

203.67

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

[1]Schwaninger AE, et al. Urinary excretion kinetics of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and its phase I and phase II metabolites in humans following controlled MDMA administration. Clin Chem. 2011 Dec;57 (12) :1748-56. |[2]Carvalho M, et al. Hepatotoxicity of 3,4-methylenedioxyamphetamine and alpha-methyldopamine in isolated rat hepatocytes: formation of glutathione conjugates. Arch Toxicol. 2004 Jan;78 (1) :16-24.|[3]Waldmeier P, et al. On the role of alpha-methyldopamine in the antihypertensive effect of alpha-methyldopa. Naunyn Schmiedebergs Arch Pharmacol. 1975;289 (3) :303-14.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W701743/

Reference compound1

No Development Reported