3,4,5-Trimethoxykaneelzuur (standaard)

3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifolia WILLD, with anti-stress effect, prolonging the sleeping time in animals[1][2]. 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits[2].

90-50-6

12352005

Endogenous Metabolite; GABA Receptor

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Neurological Disease

COC1=C(OC)C(OC)=CC(/C=C/C(O)=O)=C1

C12H14O5

238.24

[1]Kawashima K, et al. Anti-stress effects of 3,4,5-trimethoxycinnamic acid, an active constituent of roots of Polygala tenuifolia (Onji) . Biol Pharm Bull. 2004 Aug;27 (8) :1317-9.|[2]Lee CI, et al. 3,4,5-Trimethoxycinnamic acid (TMCA), one of the constituents of Polygalae Radix enhances pentobarbital-induced sleeping behaviors via GABAAergic systems in mice. Arch Pharm Res. 2013 Oct;36 (10) :1244-51.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W012123R/

Reference Standards