3,9-Dimethyl-3,9-diazaspiro[5,5]undecaan

3,9-Dimethyl-3,9-diazaspiro[5.5]undecane is a rigid PROTAC linker can be used in the synthesis of PROTACs, such as FIP22. FIP22 is a potent and selective IRAK4 PROTAC degrader with anti- atopic dermatitis activity[1].

93004-48-9

12352005

H302, H315, H319, H335

PROTAC Linkers

PROTAC

Inflammation/Immunology

99.98

CN(CC1)CCC21CCN(C)CC2

C11H22N2

182.31

H302, H315, H319, H335

[1]Fan Y, et al. Discovery of Rigid Linker-Based IRAK4 PROTACs with Improved Metabolic Stability for the Treatment of Inflammatory Diseases. J Med Chem. 2025 Aug 28;68 (16) :17874-17896.

Room Temperature

4°C (Powder, protect from light, stored under nitrogen)

http://file.medchemexpress.com/batch_PDF/HY-46871/3-9-Dimethyl-3-9-diazaspiro-5-5-undecane-SDS-MedChemExpress.pdf

Reference compound2

No Development Reported