(3R,5R) -3,5-Dihydroxy-4,7-bis (3,4-dihydroxyfenyl) piperazine-3-O-β-D-glucopyranoside

(3R,5R) -3,5-Dihydroxy-1,7-bis (3,4-dihydroxyphenyl) heptane 3-O-β-D-glucopyranoside is a diarylheptanol glycoside compound isolated from Tacca plantaginea. (3R,5R) -3,5-Dihydroxy-1,7-bis (3,4-dihydroxyphenyl) heptane 3-O-β-D-glucopyranoside significantly inhibit TNF-α-induced NF-κB transcriptional activity (IC50 = 9.4 μM) . (3R,5R) -3,5-Dihydroxy-1,7-bis (3,4-dihydroxyphenyl) heptane 3-O-β-D-glucopyranoside significantly activates PPAR transcriptional activity (EC50 = 9.9 μM) and has a specific activating effect on PPAR β (δ) (EC50 = 23.1 μM) . (3R,5R) -3,5-Dihydroxy-1,7-bis (3,4-dihydroxyphenyl) heptane 3-O-β-D-glucopyranoside is non-toxic to cells at the tested concentration. (3R,5R) -3,5-Dihydroxy-1,7-bis (3,4-dihydroxyphenyl) heptane 3-O-β-D-glucopyranoside can be used for research on inflammatory conditions[1].

408324-05-0

12352005

NF-κB; PPAR

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor

Inflammation/Immunology

OC(C=C1CC[C@H](C[C@H](O)CCC2=CC(O)=C(C=C2)O)O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)=C(C=C1)O

C25H34O11

510.53

[1]Quang TH, et al. Diarylheptanoid glycosides from Tacca plantaginea and their effects on NF-κB activation and PPAR transcriptional activity. Bioorg Med Chem Lett. 2012 Nov 1;22 (21) :6681-7.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N16637/

Natural Products

No Development Reported