4-1BB Ligand/TNFSF9 Proteïne (menselijke hFc dag)

4-1BB ligand is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as dendritic cells, macrophages, and activated B cells. Members of the TNF-TNF receptor superfamily have been shown to play critical roles in regulating cellular activation, differentiation and apoptosis. Several studies have reported that 4-1BBL/4-1BB interaction provided a co-stimulatory signal to T cells, and increased T cell proliferation and cytokines production. In addition, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.

4-1BB-L Protein; Cd137l Protein; Cd157l Protein; Ly63l Protein; Tnfsf9 Protein

NP_033430.1

Mouse

Mouse

HFc-Tag

See Datasheet send with the product

< 1.0 EU per μg protein as determined by the LAL method.

≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.

Immobilized Recombinant Mouse TNFRSF9 / CD137 / 4-1BB Protein at 2μg/mL (100μL/well) can bind Recombinant Mouse 4-1BB Ligand/TNFSF9 Protein, the EC50 is 2-6 ng/mL.

466

Lyophilized

PBS, pH 7.4

See Datasheet send with the product

51.4 kDa

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

HEK 293 cells