4-Acetylaminoantipyrine-d3

4-Acetylaminoantipyrine-d3 is the deuterium labeled 4-Acetylaminoantipyrine. 4-Acetylaminoantipyrine (4-AA) is a derivative of antipyrine (HY-B0171). 4-Acetylaminoantipyrine acts as a PGE2-dependent blocker and inhibitor of cyclooxygenase (COX). 4-Acetylaminoantipyrine can inhibit Cu/ZnSOD[2]. 4-Acetylaminoantipyrine can spontaneously bind with bovine serum albumin (BSA) and alter its conformation[3].

342821-66-3

12352005

COX; Isotope-Labeled Compounds; PGE synthase; SOD

Immunology/Inflammation; Others

Cancer-programmed cell death

Cancer

O=C1N(C2=CC=CC=C2)N(C(C)=C1NC(C([2H])([2H])[2H])=O)C

C13H12D3N3O2

248.30

[1]Berno CR, et al. Aminoantipyrine reduces toxic and genotoxic effects of doxorubicin, cisplatin, and cyclophosphamide in male mice. Mutat Res Genet Toxicol Environ Mutagen. 2016 Jul;805:19-24. |[2]Teng Y, et al. Insights into potentially toxic effects of 4-aminoantipyrine on the antioxidant enzyme copper-zinc superoxide dismutase. J Hazard Mater. 2013 Nov 15;262:318-24.|[3]Teng Y, et al. The interaction between 4-aminoantipyrine and bovine serum albumin: multiple spectroscopic and molecular docking investigations. J Hazard Mater. 2011 Jun.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W268542S1/

Isotope-Labeled Compounds

No Development Reported