4-Desmethyl-2-methylcelecoxib

4-Desmethyl-2-methyl celecoxib (Compound 1g) is an orally active and selective Cyclooxygenase-2 (COX-2) inhibitor with an IC50 value of 0.069 μM. 4-Desmethyl-2-methyl celecoxib shows anti-inflammatory, analgesic, and antipyretic activities. 4-Desmethyl-2-methyl celecoxib can reduces the synthesis of prostaglandins. 4-Desmethyl-2-methyl celecoxib is promising for research of inflammatory diseases and pain-related diseases, such as rheumatoid arthritis and osteoarthritis[1].

170569-99-0

12352005

H360-H373-H411

COX

Immunology/Inflammation

Inflammation/Immunology

O=S(C1=CC=C(N2N=C(C(F)(F)F)C=C2C3=CC=CC=C3C)C=C1)(N)=O

C17H14F3N3O2S

381.37

P260-P273-P280-P391

[1]Penning TD, et al. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5- (4-methylphenyl) -3- (trifluoromethyl) -1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib) . J Med Chem. 1997 Apr 25;40 (9) :1347-65.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-Z7640/

Reference compound2

No Development Reported

COX-2