4-Hydroxymethylpyrrolidon (standaard)

4-Hydroxymethylpyrazole (Standard) is an analytical standard for 4-Hydroxymethylpyrazole. This product is intended for research and analytical applications. 4-Hydroxymethylpyrazole is the primary metabolite of fomepizole (HY-B0876) via hepatic oxidative metabolism. 4-Hydroxymethylpyrazole exhibits a plasma concentration that is positively correlated with the administered dosage of Fomepizole, and it demonstrates a relatively short half-life. 4-Hydroxymethylpyrazole inhibits alcohol dehydrogenase (ADH) in humans and monkeys, but the inhibition constant is much higher than that of fomepizole and is therefore negligible in vivo[1]

25222-43-9

12352005

Drug Metabolite; Reference Standards

Metabolic Enzyme/Protease; Others

Metabolic Disease

OCC1=CNN=C1

C4H6N2O

98.11

[1]R Blomstrand, et al. Pyrazoles as Inhibitors of Alcohol Oxidation and as Important Tools in Alcohol Research: An Approach to Therapy Against Methanol Poisoning. Proc Natl Acad Sci U S A . 1979 Jul;76 (7) :3499-503.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-33914R/

Reference Standards