4-Methyl-1-fenyl-2-pentaanon (standaard)

Chlorpromazine (hydrochloride) (Standard) is the analytical standard of Chlorpromazine (hydrochloride) . This product is intended for research and analytical applications. Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis[1][2][3][4][5].

5349-62-2

12352005

Endogenous Metabolite; Reference Standards

Metabolic Enzyme/Protease; Others

Metabolic Disease

CC(C)CC(CC1=CC=CC=C1)=O

C12H16O

176.26

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W041470R/

Reference Standards

5-HT2 Receptor