4-Methylumbelliferyl-α-L-iduronide-2-sulfaat (natrium)

4-Methylumbelliferyl-α-L-iduronide 2-sulfate (4-MU-α-idoa 2-sulfate) sodium is a fluorogenic substrate of iduronate-2-sulfatase (I2S). 4-Methylumbelliferyl-α-L-iduronide 2-sulfate sodium can be hydrolyzed by lysosomal enzyme α-l-iduronidase (IDUA) and release the fluorophore 4-Methylumbelliferone. 4-Methylumbelliferyl-α-L-iduronide 2-sulfate sodium can be used to detect Hurler syndrome[1][2].

2181774-46-7

4-MU-α-idoa 2-sulfate (sodium)

12352005

Fluorescent Dye

Others

Metabolic Disease

O=S(O[C@H]([C@H]([C@@H]([C@@H](O1)C(O[Na])=O)O)O)[C@@H]1OC2=CC=C(C(C)=CC(O3)=O)C3=C2)(O[Na])=O

C16H14Na2O12S

476.32

[1]Azadeh M, et al. A Rapid Two-Step Iduronate-2-Sulfatatse Enzymatic Activity Assay for MPSII Pharmacokinetic Assessment. JIMD Rep. 2018;38:89-95. |[2]Gusarova VD, et al. Characterization of a HIR-Fab-IDS, Novel Iduronate 2-Sulfatase Fusion Protein for the Treatment of Neuropathic Mucopolysaccharidosis Type II (Hunter Syndrome) . BioDrugs. 2023 May;37 (3) :375-395.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W654272/

Reference compound2

No Development Reported