4-O-methylhonokiol (standaard)

4-O-Methyl honokiol is a natural neolignan isolated from Magnolia officinalis, acts as a PPARγ agonist, and inhibtis NF-κB activity, used for cancer and inflammation research.

68592-15-4

12352005

NF-κB; PPAR

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor

Cancer; Inflammation/Immunology

OC1=CC=C(CC=C)C=C1C2=CC(CC=C)=C(OC)C=C2

C19H20O2

280.36

[1]Lee NJ, et al. 4-O-methylhonokiol, a PPARγ agonist, inhibits prostate tumour growth: p21-mediated suppression of NF-κB activity. Br J Pharmacol. 2013 Mar;168 (5) :1133-45.|[2]Lee YJ, et al. Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models. J Neuroinflammation. 2012 Feb 19;9:35.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-U00450R/

Reference Standards